2025 NFL Off Season Updates Presented by GoldSheet | San Francisco 49ers
After finishing last in the NFC West last season, the San Francisco 49ers have opened as the favorites to win the division in 2025. Kyle Shanahan and Co. have been tasked with replacing several key pieces.
2025 San Francisco 49ers Team Preview
NFC West Odds
| Team | SB LX Odds | NFC | Division | Win Total |
| 49ers | +2000 | +1000 | +135 | 10.5 (o +110 / u -130) |
| Rams | +2200 | +1100 | +175 | 9.5 (o -130 / u +110) |
| Seahawks | +7500 | +3500 | +550 | 8.5 (o +115 / u -140) |
| Cardinals | +7500 | +3500 | +600 | 8.5 (o EV / u -120) |
Odds above courtesy of DraftKings as of April 16. The San Francisco 49ers finished last in the NFC West last season going 6-11 straight-up, 5-12 against the spread.
San Francisco 49ers Roster Moves
QBs on Roster: Brock Purdy (4th Year); Mac Jones (1st Year w/ Team); and Tanner Mordecai (2nd Year w/ Team)
Coaching Changes: Kyle Shanahan returns as head coach and play caller. Former Jets head coach Robert Saleh returns to his old stomping grounds to lead the defense, where he served as defensive coordinator from 2017-2021.
Key Acquisitions: Wide receiver Demarcus Robinson; Safety Jason Pinnock; Tight end Luke Farrell; and reserve QB Mac Jones
Key Departures: Wide receiver Deebo Samuel; Defensive lineman Javon Hargrave; Cornerback Charvarius Ward; Edge rusher Leonard Floyd; Linebacker Dre Greenlaw; Offensive lineman Aaron Banks; Offensive lineman Jaylon Moore; Safety Talanoa Hufanga; Running back Elijah Mitchell; and running back Jordan Mason
2025 San Francisco 49ers Schedule
Home Opponents: Cardinals, Rams, Seahawks, Falcons, Panthers, Jaguars, Titans and Bears
Road Opponents: Cardinals, Rams, Seahawks, Browns, Texans, Colts, Saints, Giants and Bucs
2025 NFL Rule Changes
- Touchbacks on a kickoff will now give the receiving team the ball on the 35-yard line instead of the 30 in an effort to increase more kick returns and discourage touchbacks.
- The regular season overtime rules will now match the postseason overtime rules, as both teams will now have an opportunity to possess the ball regardless of the outcome of the first drive. Per Jon Ferrari of the Eagles, 37.5-percent of last year’s overtime games ended with a first-drive touchdown. The new rule will allow both teams to have the ball.
- The video review booth will have an increased role in assisting the on-field officials. The video assistants can’t put a flag on the field if they believe that the officials missed a call, but they can pick one up if an erroneous flag is thrown (i.e. a facemask penalty is called, but upon video review, it’s determined that the facemask was never actually grabbed).
- Artificial intelligence and lasers will be used to determine the remaining yardage for a first down. The officials are still responsible for spotting the football just like they always have, but technology will now do the job of the chain gang and they will no longer have to run in from the sidelines for a first down measurement. Once the official places the ball down, lasers will determine if the offense reached the first down line and/or how far away they are from reaching that mark.
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WagerTalk Live Odds Screen
WagerTalk’s live odds screen features up-to-the-minute lines from a variety of offshore and domestic sports books. Track the moneylines, point spreads, totals and betting percentages for all of the San Francisco 49ers games from their release in May all the way through Week 1 in September. Find free NFL picks from season win total bets through Super Bowl futures on our free picks pages.
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