Best Home Run Prop Bets Today – HR Prop Picks For Wednesday, April 23

The 2025 MLB season is here, and who doesn’t love home run prop bets? Tons of home runs were hit last season and we’re ready to pick more winners in 2025! Free home run prop picks each day come at you compliments of WagerTalk.

Let’s see if we can beat the books with home run prop bets on Friday! You can find free MLB picks every day at WagerTalk! Here are the best home run prop bets to make for Wednesday, April 23.

Best Home Run Prop Bets – MLB Free HR Props Picks

Brandon Lowe (TB) +500

We’re targeting a lefty vs lefty matchup in the Rays vs Diamondbacks game tonight with Brandon Lowe of the Rays going up against Eduardo Rodriguez who gets the start for Arizona.

While Lowe doesn’t have much success against lefties this season yet, last season he batted .265 with a .529 slugging percentage against lefties compared to a .240 average and .461 slugging percentage against righties.

Lowe also had general success when playing the Diamondbacks last season going 5-13 with two home runs and against Rodriguez all time the Rays second baseman is 4-17 with three home runs.

Rodriguez has allowed two home runs in 22 innings this season and although neither were to a left handed batter, he has still allowed lefties to bat .321 on the season and last season Rodriguez allowed a home run to a left handed batter once every 18 at-bats while allowing righties to hit one every 28 at-bats.

It’s also worth noting that Rodriguez allowed six of his eight total home runs at home last season as well. Take Lowe to hit a home run at +500 with other Rays hitters to consider for a home run being Junior Caminero (+560) and Christopher Morel (+540).

MLB HR Props Best Bet of the Day #2: Marcus Semien (TEX) +470

It’s been a rough start to the 2025 MLB season for Marcus Semien batting .160 on the season although he did hit his second home run last night while racking up four RBIs as well.

We’re going to take him to hit a home run tonight as there were four separate instances last season when Semien hit home runs in back-to-back games.

Lefty JP Sears starts tonight for the Athletics in which Semien is 6-22 with two home runs all-time against.

Sears has given up three home runs in 23 innings this season while with two of his four starts coming against the White Sox and Rockies which isn’t exactly the best of competition.

Semien is picked up last night where he left off last season batting .321 with two home runs against the Athletics last season.

Take Semien to hit a home run tonight at +470 odds with other Rangers batters to look at for a home run include Adolis Garcia (+370) and Jake Burger (+400).

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