The Rams are in Arizona to face the Cardinals. Sean McVay has owned this series. He's 13-2 straight up, including a playoff win, and has never lost to the Cardinals in Arizona. The Rams will be without Puka Nakus who is on IR, but Cooper Kupp had a resurgence in Week 1 with 14 receptions for 110 yards and a touchdown. The Rams defense, now without Aaron Donald, managed to keep the Lions potent offense to just 20 points in regulation. The Arizona defense will likely be one of the worst in the league this year and Matt Stafford can take advantage. Kyler Murray has played 8 games against the Rams. He averages 241 yards passing and has just 8 touchdowns and 6 interceptions. Plus, we have the far superior coach with Sean McVay.