With a fully healthy Kyler Murray and the addition of Marvin Harrison Jr., the Cardinals offense is set to be even more potent. Against a Bills defense now without Matt Milano, the Cardinals should find it easier to move the ball, leveraging Murray's versatility and Harrison’s explosiveness to exploit a Buffalo defense that lacks cohesion. Not to mention they have James Conner leading the ground game.

The Cardinals will capitalize on the Bills' unsettled offense. Buffalo’s best route to success would have been attacking Arizona’s vulnerable secondary, but their new-look receiving corps may struggle to sync up quickly. Arizona's defensive strategy should involve applying pressure on Josh Allen and taking advantage of Buffalo’s less-than-ideal focus, with the Bills likely looking ahead to their critical upcoming matchup against the Dolphins on Thursday.

The Cardinals are well-positioned to cover due to their underestimated offense. With the Bills potentially distracted by the lookahead spot, Arizona could control the game tempo and exploit mismatches.

I’ll take the Cardinals plus the points.