Indianapolis went 9-8 last season is 13-19 during their previous 32 games played. Counting the postseason, Houston went 11-8 a season ago.  This sets up an extremely successful NFL betting angle displayed below.

Any NFL away favorite of 2.5 or more, that's playing in their season opener, and they won 9 or more games the previous season, versus an opponent that won 9 or more games the year before, and has won 23 or fewer of their last 32 games, resulted in those away favorites going 15-1 SU&ATS (93.7%) since 2004. This exact betting angle is also 10-0 SU&ATS since 2009 and with an average victory margin of 20.9 points per game. 

Give me the Houston Texans minus points.